A planning application has been submitted to Westminster City Council for the proposed Paddington Hub, a clinical life sciences development at the former Imperial College Medical School site adjacent to St Mary’s Hospital.

Promoted by Cohort Ltd, the scheme aims to deliver a purpose‑built facility focused on translational research — turning scientific breakthroughs “from bench to bedside” and accelerating clinical trials and patient care. The site has been vacant since Imperial College relocated its medical school to White City.

If approved, the development would support improved health outcomes, create high‑quality jobs and embed long‑term partnerships with local schools and institutions to inspire the next generation of scientists. Plans include dedicated clinical trials space, potential education and engagement facilities, and public‑realm improvements along Praed Street, including safer, greener walkways and enhanced ground‑floor areas.

The hub is expected to generate significant economic impact, with up to 1,845 on‑site roles when operational and a projected £2.5bn–£3bn in economic activity over ten years, including supply chain and induced employment. The project also anticipates job opportunities for local Westminster residents, apprenticeships and early‑career placements.

Organisers say the development will help meet undersupplied demand for high‑quality lab and clinical space in London, where only around 23% of active demand is currently met. The building is targeting BREEAM Outstanding certification, setting a new benchmark for sustainability in science and healthcare innovation in the capital.

Supporters describe the Paddington Hub as a catalyst for local economic growth and improved clinical research inclusion, with potential benefits for tackling health inequalities and strengthening London’s position at the forefront of global medical science.